It is a global first in class company based in China. It mainly focuses on the field of innovative drugs, and its products cover the research, development and industrialization of innovative drugs based on the regulation of endoplasmic reticulum / ER stress signal pathway; Develop first in class small molecule drugs to treat major diseases such as obesity, fatty liver, organ fibrosis and tumor.
Work in concert with partners in molecular and cellular biology, pharmacology, molecular informatics, ADME, structural biology, chemical development, and other key functions.
Analyze screening data, perform literature reviews, design, propose, and execute medicinal chemistry plans, coordinate chemistry and biology data to support compound progression and patent strategies;
Involve in supervising and/or directing synthetic chemistry activities internally;
Participate in shaping and implementing strategies that support Medicinal Chemistry growth objectives;
Serve as a scientific expert in medicinal chemistry and provide recommendations regarding new targets and emerging external opportunities.
PhD in synthetic or medicinal chemistry is required, preferably with postdoctoral experience
At least 10+ years of experience in the biotechnology or pharmaceutical industry with a proven track record of innovative projects and key contributions to clinical candidate selection.
Broad experience and proven accomplishments in a field of Medicinal Chemistry, preferably in one or more fields of oncology, immunology and virology, with operational skills for managing discovery programs at the level of a team head and a proven track record of delivering clinical candidates is much desirable.
Expert knowledge of modern methods of synthetic and medicinal chemistry with ability to successfully and simultaneously conduct medicinal chemistry on multiple projects is required
Solid understanding of cellular /molecular biology, biochemistry, disease pharmacology, mechanisms of drug metabolism and molecular toxicology, pharmaco-kinetic and pharmaco-dynamic sciences, and the formulations for the in vivo evaluation of drug candidates is required
Strong knowledge of computational chemistry methods and working knowledge of biophysical methods.
Professional management team
Competitive salary and benefit